As many on the internet often proclaim, tolerance is a b*tch. Almost any medication that has fast acting and reliable effects causes a tolerance of some sort. The reason for this varies somewhat from compound to compound, but overall the mechanisms of tolerance tend to be quite similar.
When you take any compound daily, your body quickly realizes that it needs to achieve homeostasis and adapt to its new environment. In a way, tolerance is an effect of evolutionary biology. With compounds such as kratom, or anti-anxiety medication, or even stimulants, once the compound is absorbed, it effects certain receptors; in the case of kratom, the receptors effected are the mu-opiod receptors and adrenergic receptors.
The effects on the mu-opiod receptors cause the painkilling and euphoric effects that kratom is well-known for. However, when you take kratom daily, the levels of alkaloids remains fairly constant in the brain, and your body adapts by increasing receptor sites for these compounds within the brain; this means that it takes more of the compound to achieve full receptor action. Additionally, it is speculated that the body creates natural peptides which act as an opiod antagonist to counteract the effects of the compound, though we don’t yet know how much of a role they play.
Because the effects of kratom can wane dramatically when taken every day, it is essential to avoid building a kratom tolerance if you want to achieve the peak effects. This can be done through a few different methods. The first method is obviously to take less kratom, or to space kratom dosage out further. This will ensure that the levels of kratom alkaloids don’t remain at a constant level throughout the day, decreasing the body’s tolerance reaction.
If you must take kratom daily due to a medical condition, or as a maintenance drug for opiate addiction, another way to reduce kratom tolerance is to cycle your kratom strains. This is best done with at least 4 different strains. Each day, you will want to take a strain different from the day before, preferably, the least similar. Because different kratom strains have different alkaloids, the body doesn’t adapt to a specific set of alkaloids as quickly.
There are a few compounds that can reduce or delay the development of tolerance, such as magnesium. Because magnesium acts at NMDA receptors, which are primarily responsible for the development of tolerance, it can reduce the likelihood of high tolerance acquisition.
Overall, the best way to reduce tolerance is to take kratom less, however, in some cases, that is not a possibility. If so, try to keep your tolerance low by taking breaks as often as possible. This will keep the plant functioning at full efficiency.